WebApr 7, 2024 · Ischemic cardiomyopathy, driven by loss of cardiomyocytes and inadequate proliferative response, persists to be a major global health problem. Using a functional high-throughput screening, we assessed differential proliferative potential of 2024 miRNAs after transient hypoxia by transfecting both miR-inhibitor and miR-mimic libraries in human … WebOct 10, 2024 · Cancer immunotherapy often depends on recognition of peptide epitopes by cytotoxic T lymphocytes (CTLs). The tumor microenvironment (TME) is enriched for peroxynitrite (PNT), a potent oxidant produced by infiltrating myeloid cells and some tumor cells. We demonstrate that PNT alters the profile of M …
Animal models of pulmonary hypertension due to left heart disease
WebFeb 7, 2024 · Background: Deep phenotyping and longitudinal assessment of predementia at-risk states of Alzheimer's disease (AD) are required to define populations and outcomes for dementia prevention trials. Subjective cognitive decline (SCD) is a pre-mild cognitive impairment (pre-MCI) at-risk state of dementia, which emerges as a highly promising … Web4 Department of Orthopaedic Surgery and Traumatology, Charité Berlin, University Hospital, Chariteplatz 1, 10117, Berlin, Germany. PMID: 37036501 DOI: 10.1007/s00402-023-04855-5 Abstract Background: Liner malseating is well described in ceramic-on-ceramic total hip arthroplasties (THAs). However, limited information is known on this ... front porch navarre
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WebJul 13, 2024 · Neutrophils are immune cells with unusual biological features that furnish potent antimicrobial properties. These cells phagocytose and subsequently kill prokaryotic and eukaryotic organisms very efficiently. Importantly, it is not only their ability to attack microbes within a constrained intracellular compartment that endows neutrophils with ... WebThe ten most selected apps (see Fig 1) comprise 38% of the app selection at initial. The top three filters informing app selections were cost (76%), condition supported by the app (59%), and app features offered (51%), as seen in Fig 2. Approximately 37% of participants reported that outside factors not included as filters in the MIND database ... WebApr 10, 2024 · DOI: 10.1038/s41467-023-37233-1 Abstract Advances in structural biology have provided important mechanistic insights into signaling by the transmembrane core of G-protein coupled receptors (GPCRs); however, much less is known about intrinsically disordered regions such as the carboxyl terminus (CT), which is highly flexible and not … front porch music valparaiso indiana