Cisplatin and creatinine clearance
WebSep 21, 2016 · Concordance between calculated and measured CrCl less than 60 mL/min was poor (range of κ, 0.14 to 0.38). In patients older than age 65, 22% had a measured … WebJan 7, 2024 · Cisplatin is used as treatment for several different malignancies and a well-known complication is irreversible kidney damage. To protect the kidneys, this treatment is often combined with mannitol infusion to promote osmotic diuresis. Earlier studies investigating the nephroprotective effect of mannitol have shown conflicting results. …
Cisplatin and creatinine clearance
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WebDec 31, 2024 · The mean renal clearance of cisplatin exceeds creatinine clearance and is 62 and 50 mL/min/m 2 following administration of 100 mg/m 2 as 2-hour or 6- to 7-hour infusions, respectively. The renal clearance of free (ultrafilterable) platinum also exceeds the glomerular filtration rate indicating that cisplatin or other platinum-containing ... WebHigher cisplatin delivery rates led to higher peak concentrations of free Pt in plasma and urine and to lower cumulative renal Pt elimination (P < 0.01). During all courses, increases of urinary albumin and alpha1-microglobulin excretion were documented. The creatinine clearance decreased significantly to 70% of baseline values.
WebFeb 16, 2016 · All patients were treated with high-dose cisplatin CCRT. The main outcome parameters were nephrotoxicity (defined as creatinine clearance grade 2 or more) and … WebSep 4, 2013 · The dose of cisplatin was reduced by 25% in all the subsequent cycles if the serum creatinine level increased to Grade 2 or higher. Statistical Analyses This study was designed as a nonrandomized, single-center Phase II trial.
WebFeb 16, 2016 · In cisplatin-based CCRT schedules, acute nephrotoxicity is commonly graded by an increase of serum creatinine levels, according to the Common Terminology Criteria for Adverse Events (CTCAE). Using these criteria nephrotoxicity ≥grade 3 occurs in only 4%–9% of patients [ 7, 10, 11 ]. WebA repeat course of cisplatin should not be given until: the serum creatinine is below 140micromol/L and/or the plasma urea is below 9mmol/L and circulating blood elements are at an acceptable level (platelets at least 100,000/mm3, WBC at least 4000/mm3). A base line audiogram should be taken and the patient monitored periodically for auditory
WebFeb 9, 2024 · Creatinine clearance is a measure of how well the kidneys filter creatinine out of the bloodstream for excretion in urine. Creatinine clearance is usually determined …
WebAug 30, 2024 · Cisplatin Injection, is a clear, light-yellow, sterile aqueous solution, for intravenous use, available in sterile multiple-dose vials containing - 50 mg/50 mL (1 mg/mL) 100 mg/100 mL (1 ... 4 CONTRAINDICATIONS Cisplatin Injection is contraindicated in patients with severe hypersensitivity to cisplatin [see Warnings and Precautions (5.4)]. razor wizard running after uninstallWebwith three cycles of cisplatin 70 mg/qm2 on day 1 and methotrexate 40 mg/qm2 on days 8 and 15 of a 21-day cycle (CM) or three cycles of methotrexate 30 mg/qm2 on days 1, 15, and 22, vinblastine 3 mg/qm2 on days 2, 15, and 22, epirubicin 45 mg/qm2 on day 2, and cisplatin 70 mg/qm2 on day 2 of a 28-day cycle (M-VEC). Results sims 1 hd modWebDec 16, 2024 · Cisplatin (CDDP; cis-dichlorodiammine platinum [II]) is a non-specific drug of the cell cycle with strong cytotoxicity and broad-spectrum antitumor effects; it is widely used in urogenital system tumors, malignant lymphoma, breast cancer, head and neck cancer, non-small cell lung cancer, etc. ( 1 – 3) Cisplatin-induced nephrotoxicity is … razor with worker process memoryWebWe aimed to evaluate the correlation of serum cystatin C levels with the serum creatinine levels and GFR calculated by Cockcroft-Gault and modification of diet in renal disease (MDRD) formulations in the patients who received cisplatin-based chemotherapy. razor wolf genshin impactWebCisplatin-eligible subjects receive: gemcitabine 1000mg/m2 IV D1 and D8 every 21 days repeated for 4 cycles; cisplatin 70mg/m2 IV D1 and D8 every 21 days, repeated for 4 cycles. ... Glomerular filtration rate (GFR) or creatinine clearance (Ccr) ≥ 50 mL/min. (24 hour urine preferred). The cisplatin dose will be split over two days for values ... razor work shirtWebMeasure serum creatinine, blood urea nitrogen, creatinine clearance, and serum electrolytes including magnesium prior to initiating therapy, and as clinically indicated. … razor won\u0027t shave white hairsWebSep 16, 2024 · Cisplatin produces cumulative nephrotoxicity which is potentiated by aminoglycoside antibiotics. The serum creatinine, blood urea nitrogen (BUN), creatinine clearance, and magnesium, sodium ... PRECAUTIONS Peripheral blood counts should be monitored weekly. Liver function should be monitored periodically. razor wood file