WebIRF4 Is Highly Induced in Graft-Infiltrating T Cells and Is Required for Heart Transplant Rejection IRF4 is a key transcription factor for translating TCR signaling into proper T cell responses ( Huber and Lohoff, 2014 ), but its role in T cell-mediated transplant rejection remains unclear. WebT cell exhaustion is characterized by high expression of inhibitory receptors and widespread transcriptional and epigenetic alterations 4, 5, 7, 18, 19, but the mechanisms responsible for...
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WebApr 18, 2024 · Rearrangements of the DUSP22-IRF4 locus are found in ∼25% of C-ALCL and in a small subset of LyP, but do not have prognostic significance. 30 Histologically, these lesions show a biphasic growth pattern with CD30 + small cerebriform lymphocytes in the epidermis and large CD30 + transformed cells in the dermis, and show reduced … WebMar 21, 2024 · IRF4 is a key regulator of mucosal IL-6 production in T cell-dependent experimental colitis and suggest that IRF4 might provide a therapeutic target for inflammatory bowel diseases. IRF-4 coordinates the two pathways regulating light-chain recombination by positioning pre-B cells away from IL-7-expressing stromal cells how to sweep for bugs and hidden cameras
BATF and IRF4 cooperate to counter exhaustion in tumor …
WebMar 29, 2024 · IRF4 on the other hand regulates cDC2 subsets, which express high levels of CD11b and CD172 in both mouse and humans and are highly efficient at inducing CD4 + T cell effector function and expansion. High expression of IRF8 in combination with E2-2 and Bcl11A are required for development of pDCs, which secrete high amounts of type I IFN in ... WebApr 13, 2024 · Front. Cell. Dev. Biol. 2024, 9, 570451.(标注基金号81960239、82060244) 论文3:Hua Fang#, Jianping Zhang* et al., Dexmedetomidine-up-regulated microRNA-381 exerts anti‐inflammatory effects in rats with cerebral ischaemic injury via the transcriptional factor IRF4. J. Cell. Mol. WebDec 6, 2024 · In agreement with the lack of a role for STAT3 in TNF-Th17 cell generation, TNF-induced IRF4 up-regulation was similar in STAT3-deficient and WT CD4 + T cells (SI Appendix, Fig. S6D). The dependence of TNF-Th17 generation on IRF4 was shown by the reduction of ROR-γt expression ( Fig. 2 J ) and IL-17A production ( Fig. 2 K ) in its absence. reading sunglasses polarized