M6a and autophagy
Web26 mar. 2024 · In eukaryotes, N 6-methyladenosine (m 6 A) is abundant on mRNA, and plays key roles in the regulation of RNA function. However, the roles and regulatory mechanisms of m 6 A in phytopathogenic fungi are still largely unknown.; Combined with biochemical analysis, MeRIP-seq and RNA-seq methods, as well as biological analysis, … Web30 oct. 2024 · The N6-methyladenosine (m6A) RNA modification can regulate autophagy to modulate the growth and development of tumors, but the mechanism of m6A …
M6a and autophagy
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WebHere, we show that m 6 A plays a critical role in regulating macroautophagy/autophagy and adipogenesis through targeting Atg5 and Atg7. Mechanistically, knockdown of FTO, … Web16 feb. 2024 · N6-methyladenosine (m6a) is associated with growth, occurrence and progression of disease and drug resistance of cancer cells. A study found that METTL3-mediated m6a methylation inhibited...
Web20 apr. 2024 · N6-methyladenosine (m 6 A) is the most common and conserved internal eukaryotic mRNA modification. m 6 A modification is a dynamic and reversible post-transcriptional regulatory modification, initiated by methylase and removed by RNA demethylase. m 6 A-binding proteins recognise the m 6 A modification to regulate gene … Web5 mai 2024 · N6-methyladenosine (m 6 A) is an abundant nucleotide modification in mRNA, known to regulate mRNA stability, splicing, and translation, but it is unclear whether it is also has a physiological role in the intratumoral microenvironment and cancer drug resistance.
Web9 aug. 2024 · There were differences in m6A levels and immune cell infiltration between the high- and low-risk groups. Conclusions: Our prognostic model of the seven m6A-related autophagy genes had significant predictive value for LUSC; thus, these genes may serve as autophagy-related therapeutic targets in clinical practice. Keywords: N6 … Web1 aug. 2024 · To be specific, m6A-modified genes are involved in body metabolism and autophagy ( 12 ). All this weight of evidence implies that aberrant m6A modification may underlie the autoimmunity and dysfunction of other important pathological processes through various mechanisms ( 13, 14 ).
WebMechanically, the m6A modification of TMA7 is regulated by IGF2BP3, which further induces autophagy and cisplatin resistance by regulating UBA2 in LSCC cells. Taken together, these results suggested that targeting the IGF2BP3/TMA7/UBA2 axis may be a novel and promising therapeutic approach for LSCC. Results
Web31 dec. 2024 · This review summarizes the roles of m6A regulators in cancer initiation and progression, autophagy, and anticancer drug resistance. The review also discusses the relationship between autophagy and anticancer drug resistance, the effect of high levels of m6A on autophagy and the potential values of m6A regulators as diagnostic markers … community health network medcheck near meWeb26 aug. 2024 · Here, we show that m6A plays a critical role in regulating macroautophagy/autophagy and adipogenesis through targeting Atg5 and Atg7. Mechanistically, knockdown of FTO, a well-known m6A... community health network medcheck locationsWeb14 mar. 2024 · This study explored the role of m 6 A modification in the autophagy of cardiomyocytes treated with hypoxia/reoxygenation (H/R) and addressed the mechanisms by which m 6 A participates in the ischemic heart disease. Results H/R induces METTL3 upregulation in cardiomyocytes, which accounts for the aberrant m 6 A modification community health network medcheckWeb11 apr. 2024 · Recent studies demonstrate that macroautophagy/autophagy is essential to maintain architecture and function of β-cells, whereas excessive autophagy is also involved in β-cell dysfunction and death. It has been poorly understood whether autophagy plays a protective or harmful role in β-cells, while we report here that it is dependent on NR3C1 ... community health network medcheck eastcommunity health network medcheck noblesvilleWeb3 iun. 2024 · We found that m6A demethylase fat mass and obesity-associated protein (FTO) plays a key role in regulating autophagy and tumorigenesis by targeting the gene encoding eukaryotic translation... community health network medcheck greenwoodWeb20 sept. 2024 · Second, the further exploration of the interaction between m6A and autophagy in the gland tissues and the difference in the expression pattern with PB was … community health network medcheck fishers