Shank2 gene in hcc
Webb15 maj 2004 · The present study utilized bioinformatics to demonstrate the presence of exons encoding ankyrin repeats in the region preceding the previously described Shank2 gene. cDNA sequencing of mRNA from epithelial cells revealed a novel spliceoform of Shank2, termed Shank2E, that encodes a predicted 200 kDa protein with six N-terminal … Webb13 juli 2024 · Interestingly, a mammalian homolog of Prosap, SHANK2, is the most frequently amplified gene on 11q13, a major tumor amplicon in human cancer. Gene …
Shank2 gene in hcc
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Webb7 maj 2024 · Although rare, chromothripsis, multiple structural rearrangements in single catastrophic mitosis, was also reported in HCC [ 5 ]. A broad range of cancer-related … Webb14 juni 2012 · Shank2 (also known as ProSAP1) is a multi-domain scaffolding protein and signalling adaptor enriched at excitatory neuronal synapses, and mutations in the human SHANK2 gene have recently been...
WebbThe range of conditions associated with SHANK2 deletions suggests that other factors are involved in its link to autism, says Bourgeron. Other genes, for instance, seem to play a … WebbA downregulation of CPS1 has frequently been associated with HCC in literature. 7,8,22 The upregulation of CAD in HCC, which has been previously reported, was hypothesized to be linked to the downregulation in CPS1 through an increased availability of glutamine due to the halting of urea cycle. 23–25 This study aimed to develop a network which explored …
WebbThis gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular sca ffolds in the postsynaptic density of excitatory synapses. …
WebbThe alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank … cuba gooding jr.\u0027s mother shirley goodingMutations in SHANK2 have been associated with autism spectrum disorder (ASD) and schizophrenia. In particular, heterozygous loss-of-function mutations have a near-complete penetrance in ASD. Neurons generated from people with ASD and SHANK2 mutations develop larger dendritic trees and more synaptic connections than those from healthy controls. In addition, common mutations in SHANK2 have been linked to bipolar disorder. east baton rouge inmate lookupWebbGene target information for SHANK2 - SH3 and multiple ankyrin repeat domains 2 (human). Find diseases associated with this biological target and compounds tested against it in … east baton rouge gis mappingWebb4 apr. 2024 · Several studies aimed to construct effective predictive models in HCC previously, including deep learning-based multi-omics model, radiomics model and gene signature models [2–6]. Studies have proved that m6A-related genes, ferroptosis-related genes, and aging-related genes were all associated with cancer prognosis [ 7 , 8 ]. cuba gooding junior boxing moviehttp://www.protein-cell.org/en/article/doi/10.1007/s13238-020-00742-6 east baton rouge jail inmate searchWebbThe SHANK2 gene, located on the 11th chromosome, provides the code for producing SHANK2 protein which is essential for proper brain function. SHANK2 protein plays an … cuba gooding jr wife and kidsWebb25 sep. 2024 · Genetic defects in the SHANK2 gene, encoding for synaptic scaffolding protein, are associated with a variety of neurodevelopmental conditions, including autism spectrum disorders and mild to... cuba gooding junior diving movie